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- Table of Contents
APC Antibodies
AND APC ELISA kits, APC Proteins
Many biological assays use antibodies to detect APC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with APC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop APC antibodies...
Designing an IHC experiment for APC? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the APC IHC GuideAPC Infographic by Boster Bio
All APC Products
Product
Figures
Specificity
Applications
Price
Rat
ELISA
$499
Cat # EK1209
96 wells/kit, with removable strips.
Cat # EK1209
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # EK1557
96 wells/kit, with removable strips.
Cat # EK1557
96 wells/kit, with removable strips.
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00162
100 μg/vial
Cat # A00162
100 μg/vial
Mouse
ELISA
$499
Cat # FEK1208
96 wells/kit, with removable strips.
Cat # FEK1208
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1208
96 wells/kit, with removable strips.
Cat # EK1208
96 wells/kit, with removable strips.
Human
ELISA
$500
Cat # EZ0957
For 5 plates, 96 wells each
Cat # EZ0957
For 5 plates, 96 wells each
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A08280-2
100 μg/vial
Cat # A08280-2
100 μg/vial
Human
$628
Cat # LS051529
20 µg, 100 µg
Cat # LS051529
20 µg, 100 µg
Human
ELISA
$540
Cat # EKC2213
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2213
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1034
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1034
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2285
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2285
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00162-1
100 μg
Cat # M00162-1
100 μg
Human, Mouse
ELISA
$480
Cat # EKC1020
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1020
1 kit, containing one 96-well plate and all necessary reagents
Human
$628
Cat # LS000325
20 µg, 100 µg
Cat # LS000325
20 µg, 100 µg
Human, Mouse, Rat
ELISA
$540
Cat # EKC2239
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2239
1 kit, containing two 96-well plates and all necessary reagents
APC Overview
Facts about Adenomatous polyposis coli protein.
Adenomatous polyposis coli protein (APC)
Tumor suppressor. APC activity is correlated with its phosphorylation state.
Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | APC |
| Uniprot: | P25054 |
| Entrez: | 324 |
Family
| Belongs to: |
|---|
| adenomatous polyposis coli (APC) family |
Alternative Names
adenomatosis polyposis coli tumor suppressor; adenomatosis polyposis coli; adenomatous polyposis coli protein; adenomatous polyposis coli; APC; BTPS2; Deleted in polyposis 2.5; DP2; DP2.5DP2; DP3; FPC; GS; Min; Protein APC
Molecular Weight
Mass (kDA):
311.646 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q22.2 |
| Sequence: | 5; NC_000005.10 (112707498..112846239) |
Tissue Specificity
Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver (PubMed:21643010, PubMed:27217144). Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues (PubMed:19527921, PubMed:21643010, PubMed:27217144). Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood (PubMed:19527921, PubMed:21643010, PubMed:27217144).
Subcellular Localizations
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854).
Diseases
- Neoplasms
- Malignant Neoplasms
- Adenomatous Polyposis Coli
- Polyposis
- Colorectal Cancer
- Carcinoma
- Colorectal Neoplasms
- Adenoma
- Thrombosis
- Cell Transformation, Neoplastic
- Activated Protein C Resistance
- Carcinogenesis
- Inflammation
Interacting Proteins
- AMER1
- AMER3
- CDC42
- CSNK1E
- CTNNA1
- CTNNB1
- Ctnnb1
- DVL1
- DVL1P1
- DVL2
Pathways
- Coagulation
- Immune Response
- Cell Cycle
- Cell Activation
- Mitosis
- Cell Proliferation
- T Cell Activation
- Methylation
- Anaphase
- Pathogenesis
- Secretion
- Localization
- Proteolysis
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Ubiquitination
- Dephosphorylation
- Glycosylation
- Reduction
- Oxidation
- Biotinylation
- Acetylation
Research Areas
- Cancer
- Cell Biology
- Cell Cycle and Replication
- Tumor Suppressors
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APC
bosterbio.com/bosterbio-gene-info-cards/APC
References
PMID: 1678319 by Joslyn G., et al. Identification of deletion mutations and three new genes at the familial polyposis locus.
PMID: 1651562 by Kinzler K.W., et al. Identification of FAP locus genes from chromosome 5q21.
4 Publications of Boster APC Antibodies & ELISA Kits
- PubMed ID: 10.1155/2016/1359105, Sequential Treatments with Tongsai and Bufei Yishen Granules Reduce Inflammation...
- PubMed ID: -, Ou Qiao,Xinyu Zhang,Yi Zhang et al.Cerebralcare Granule® enhances memantine hyd...
- PubMed ID: 25608619, microRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pat...
- PubMed ID: 24194897, Li M, Tian L, Wang L, Yao H, Zhang J, Lu J, Sun Y, Gao X, Xiao H, Liu M. Plos On...
*More publications can be found for each product on its corresponding product page